Title : Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.

Pub. Date : 2016 Apr 1

PMID : 26581245






1 Functional Relationships(s)
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1 In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis. Cyclic AMP adrenoceptor beta 2 Homo sapiens