Title : Dose and Effect Thresholds for Early Key Events in a PPARĪ±-Mediated Mode of Action.

Pub. Date : 2016 Feb

PMID : 26519955






2 Functional Relationships(s)
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1 The 7-day BMDT values for Acot1 as a surrogate measure for PPARalpha activation were 29, 370, and 676 mg/kg/day for DEHP, DNOP, and BBP, respectively, distinguishing DEHP (liver tumor BMD of 35 mg/kg/day) from non-tumorigenic DNOP and BBP. Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
2 The 7-day BMDT values for Acot1 as a surrogate measure for PPARalpha activation were 29, 370, and 676 mg/kg/day for DEHP, DNOP, and BBP, respectively, distinguishing DEHP (liver tumor BMD of 35 mg/kg/day) from non-tumorigenic DNOP and BBP. Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus