Title : PEP-1-SOD1 fusion proteins block cardiac myofibroblast activation and angiotensin II-induced collagen production.

Pub. Date : 2015 Oct 7

PMID : 26446519






2 Functional Relationships(s)
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1 RESULTS: PEP-1-SOD1 fusion protein efficiently transduced into MCF, scavenged intracellular O2 (-), decreased intracellular MDA content, increased SOD activity, suppressed ANG II-induced proliferation, reduced expression of TGF-beta1, alpha-SMA, collagen type I and III, restored MMP-1 secretion, and attenuated TIMP-1 secretion. Superoxides superoxide dismutase 1 Rattus norvegicus
2 RESULTS: PEP-1-SOD1 fusion protein efficiently transduced into MCF, scavenged intracellular O2 (-), decreased intracellular MDA content, increased SOD activity, suppressed ANG II-induced proliferation, reduced expression of TGF-beta1, alpha-SMA, collagen type I and III, restored MMP-1 secretion, and attenuated TIMP-1 secretion. Superoxides superoxide dismutase 1 Rattus norvegicus