Title : Effects of nicotinic acetylcholine receptor agonists in assays of acute pain-stimulated and pain-depressed behaviors in rats.

Pub. Date : 2015 Nov

PMID : 26359313






1 Functional Relationships(s)
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1 Previous preclinical studies have implicated alpha4beta2 and alpha7 nAChRs as potential mediators of the antinociceptive effects of (-)-nicotine hydrogen tartrate (nicotine) and other nAChR agonists; however, these studies have relied exclusively on measures of pain-stimulated behavior, which can be defined as behaviors that increase in frequency, rate, or intensity after presentation of a noxious stimulus. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus