Pub. Date : 2015
PMID : 26351626
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ex vivo nicotine stimulation augments the efficacy of human peripheral blood mononuclear cell-derived dendritic cell vaccination via activating Akt-S6 pathway. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We could demonstrate that the treatment with nicotine resulted in increased surface molecules expression, enhanced hu-imDCs-mediated PBMC proliferation, upregulated release of IL-12 in the supernatant of cocultured DCs-PBMC, and augmented phosphorylation of Akt and ribosomal protein S6. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Importantly, the upregulation of nicotine-increased surface molecules upregulation was significantly abrogated by the inhibition of Akt kinase. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These findings demonstrate that ex vivo nicotine stimulation augments hu-imDCs surface molecules expression via Akt-S6 pathway, combined with increased Ag-presentation result in augmented efficacy of DCs-mediated PBMC proliferation and Th1 polarization. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |