Title : Superoxide anion-induced pain and inflammation depends on TNF╬▒/TNFR1 signaling in mice.

Pub. Date : 2015 Sep 25

PMID : 26291484






4 Functional Relationships(s)
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1 Superoxide anion-induced pain and inflammation depends on TNFalpha/TNFR1 signaling in mice. Superoxides tumor necrosis factor Mus musculus
2 Tumor necrosis factor receptor 1 deficiency (TNFR1-/-) and treatment of wild-type mice with etanercept (a soluble TNFR2 receptor that inhibits TNFalpha actions) inhibited superoxide anion-induced pain-like behaviors. Superoxides tumor necrosis factor Mus musculus
3 These results demonstrate that TNFalpha/TNFR1 signaling is important in superoxide anion-triggered pain and that TNFalpha/TNFR1 signaling amplifies the oxidative stress triggered by superoxide anion, which contributes to sustaining pain and inflammation. Superoxides tumor necrosis factor Mus musculus
4 These results demonstrate that TNFalpha/TNFR1 signaling is important in superoxide anion-triggered pain and that TNFalpha/TNFR1 signaling amplifies the oxidative stress triggered by superoxide anion, which contributes to sustaining pain and inflammation. Superoxides tumor necrosis factor Mus musculus