Title : High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice.

Pub. Date : 2015 Oct 15

PMID : 26256075






1 Functional Relationships(s)
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1 Since the selective alpha3beta4 nAChR functional antagonist AT-1001 has also been shown to block nicotine self-administration in rats, the present results suggest that alpha3beta4 nAChRs may be a target for the treatment of cocaine addiction as well as for cocaine-nicotine comorbid addiction. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus