Title : Parafibromin Is a Component of IFN-γ-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1.

Pub. Date : 2015 Sep 15

PMID : 26232434






3 Functional Relationships(s)
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Protein Name
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1 Parafibromin Is a Component of IFN-gamma-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1. Tyrosine signal transducer and activator of transcription 1 Homo sapiens
2 Overexpression of parafibromin promoted IFN-gamma-triggered phosphorylation of STAT1 at Tyr(701), subsequent expression of downstream genes, and cellular antiviral response, whereas knockdown of parafibromin had opposite effects. Tyrosine signal transducer and activator of transcription 1 Homo sapiens
3 Parafibromin interacted with JAK1/2, promoted the interactions of JAK1-JAK2 and JAK1/2-STAT1, and promoted tyrosine phosphorylation of STAT1 by JAKs after IFN-gamma stimulation. Tyrosine signal transducer and activator of transcription 1 Homo sapiens