Title : Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design.

Pub. Date : 2015 Sep 15

PMID : 26231159

1 Functional Relationships(s)
Compound Name
Protein Name
1 Stimulation with IFNalpha/beta leads to the tyrosine phosphorylation of the JAK1 and Tyk2 receptor-associated kinases with subsequent STATs activation, transmitting signals from the cell surface receptor to the nucleus. Tyrosine Janus kinase 1 Homo sapiens