Title : Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols.

Pub. Date : 2015 Sep 14

PMID : 26230055






3 Functional Relationships(s)
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Protein Name
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1 Addition of cholesterol 25-hydroperoxide to the enzymes CYP27A1 and CYP11A1 induced well-defined spectral changes while generating 25-hydroxycholesterol as the major product. 25-hydroxycholesterol cytochrome P450 family 27 subfamily A member 1 Homo sapiens
2 CYP27A1 was shown to mediate the reduction of cholesterol 25-hydroperoxide to 25-hydroxycholesterol, a role of potential significance for cholesterol-rich tissues with high oxidative stress. 25-hydroxycholesterol cytochrome P450 family 27 subfamily A member 1 Homo sapiens
3 CYP27A1 may participate in the removal of harmful autoxidation products in these tissues, while providing a complementary source of 25-hydroxycholesterol, a modulator of immune cell function and mediator of viral cell entry. 25-hydroxycholesterol cytochrome P450 family 27 subfamily A member 1 Homo sapiens