Title : Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid.

Pub. Date : 2016 Jan

PMID : 26129652






3 Functional Relationships(s)
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1 Here we show that RA acts cell intrinsically in developing gut-tropic pre-mucosal dendritic cell (pre-muDC) to effect the differentiation and drive the specialization of intestinal CD103(+)CD11b(-) (cDC1) and of CD103(+)CD11b(+) (cDC2). Tretinoin cyclin dependent kinase 1 Homo sapiens
2 Systemic deficiency or DC-restricted antagonism of RA signaling resulted in altered phenotypes of intestinal cDC1 and cDC2, and reduced numbers of cDC2. Tretinoin cyclin dependent kinase 1 Homo sapiens
3 Systemic deficiency or DC-restricted antagonism of RA signaling resulted in altered phenotypes of intestinal cDC1 and cDC2, and reduced numbers of cDC2. Tretinoin cyclin dependent kinase 1 Homo sapiens