Title : Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors.

Pub. Date : 2015 Sep

PMID : 26121313






8 Functional Relationships(s)
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1 Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 Renal prostaglandin (PG) E2 regulates salt and water transport, and affects disease processes via EP1-4 receptors, but its role in the proximal tubule (PT) is unknown. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
3 EP1 was increased by PGE2 and TGFbeta, but EP4 was unchanged. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
4 PGE2 increased p27 via EP1 and EP4, but TGFbeta increased p21; PGE2-induced p27 was attenuated by TGFbeta. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
5 PGE2 increased p27 via EP1 and EP4, but TGFbeta increased p21; PGE2-induced p27 was attenuated by TGFbeta. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
6 Na-K-ATPase alpha1 (NaK) was increased by PGE2 via EP1 and EP4. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
7 Finally, PGE2 significantly increased fluid reabsorption by 31 and 46% in isolated perfused mouse PT from C57BL/6 and FVB mice, respectively, and this was attenuated in FVB-EP1 null mice. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
8 Altogether PGE2 acting on EP1 and EP4 receptors may prove to be important mediators of PT injury, and salt and water transport. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus