Pub. Date : 2015 Oct 5
PMID : 26119915
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 2 | Since DHEA is the endogenous ligand for the sigma-1 receptor (sigma1R), we determined whether oral DHEA administration prevents neuronal cell death and improves cognition via sigma1R stimulation in brain ischemia using a 20-min bilateral common carotid artery occlusion (BCCAO) mouse model. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 3 | Since DHEA is the endogenous ligand for the sigma-1 receptor (sigma1R), we determined whether oral DHEA administration prevents neuronal cell death and improves cognition via sigma1R stimulation in brain ischemia using a 20-min bilateral common carotid artery occlusion (BCCAO) mouse model. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 4 | Since DHEA is the endogenous ligand for the sigma-1 receptor (sigma1R), we determined whether oral DHEA administration prevents neuronal cell death and improves cognition via sigma1R stimulation in brain ischemia using a 20-min bilateral common carotid artery occlusion (BCCAO) mouse model. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 5 | Since DHEA is the endogenous ligand for the sigma-1 receptor (sigma1R), we determined whether oral DHEA administration prevents neuronal cell death and improves cognition via sigma1R stimulation in brain ischemia using a 20-min bilateral common carotid artery occlusion (BCCAO) mouse model. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 6 | Moreover, DHEA administration significantly ameliorated decreases in adenosine 5"-triphosphate (ATP) levels and decreased sigma1R expression levels in CA1 following BCCAO ischemia. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 7 | Taken together, DHEA prevents neuronal cell death and activates CaMKII via sigma1R stimulation, thereby improving cognitive deficits following brain ischemia. | Dehydroepiandrosterone | sigma non-opioid intracellular receptor 1 | Mus musculus |