Pub. Date : 2015 Oct 21
PMID : 26115461
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Investigating changes in the gas-phase conformation of Antithrombin III upon binding of Arixtra using traveling wave ion mobility spectrometry (TWIMS). | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 2 | Arixtra is the smallest synthetic Hp containing the specific pentasaccharide sequence required to bind with ATIII. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 3 | Here we report the first travelling wave ion mobility mass spectrometry (TWIMS) investigation of the conformational changes in ATIII induced by its interaction with Arixtra. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 4 | Native electrospray ionization mass spectrometry allowed the gentle transfer of the native topology of ATIII and ATIII-Arixtra complex. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 5 | IM measurements of ATIII and ATIII-Arixtra complex showed a single structure, with well-defined collisional cross section (CCS) values. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 6 | An average 3.6% increase in CCS of ATIII occurred as a result of its interaction with Arixtra, which agrees closely with the theoretical estimation of the change in CCS based on protein crystal structures. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 7 | The effect of collisional activation of ATIII and ATIII-Arixtra complex were also assessed, revealing that the binding of Arixtra provided ATIII with additional stability against unfolding. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 8 | The effect of collisional activation of ATIII and ATIII-Arixtra complex were also assessed, revealing that the binding of Arixtra provided ATIII with additional stability against unfolding. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 9 | The effect of collisional activation of ATIII and ATIII-Arixtra complex were also assessed, revealing that the binding of Arixtra provided ATIII with additional stability against unfolding. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 10 | The effect of collisional activation of ATIII and ATIII-Arixtra complex were also assessed, revealing that the binding of Arixtra provided ATIII with additional stability against unfolding. | Fondaparinux | serpin family C member 1 | Homo sapiens |
| 11 | The effect of collisional activation of ATIII and ATIII-Arixtra complex were also assessed, revealing that the binding of Arixtra provided ATIII with additional stability against unfolding. | Fondaparinux | serpin family C member 1 | Homo sapiens |