Title : Anti-oxidation and Antiapoptotic Effects of Chondroitin Sulfate on 6-Hydroxydopamine-Induced Injury Through the Up-Regulation of Nrf2 and Inhibition of Mitochondria-Mediated Pathway.

Pub. Date : 2015 Jul

PMID : 26033682






1 Functional Relationships(s)
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1 6-OHDA-induced dysfunctions, including the decrease of mitochondrial membrane potential (DeltaPsim), increase of intracellular free Ca(2+), imbalance of Bcl-2/Bax ratio, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9 were attenuated by CS pretreatment, which demonstrated that CS suppressed 6-OHDA-induced apoptosis in SH-SY5Y cells possibly through mitochondria protection. Oxidopamine caspase 3 Homo sapiens