Title : c-Jun N-terminal kinase attenuates TNF╬▒ signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells.

Pub. Date : 2015 Sep

PMID : 26001727






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nuclear factor-kappa B (NF-kappaB) activation by TNFalpha requires endosomal superoxide production by Nox1. Superoxides tumor necrosis factor Homo sapiens
2 TNFalpha-stimulated superoxide generation was enhanced by JNK1 inhibition in WT, but not in Nox1 KO VSMC. Superoxides tumor necrosis factor Homo sapiens
3 JNK and endosomal superoxide may represent novel targets for pharmacologic modulation of TNFalpha signaling and vascular inflammation. Superoxides tumor necrosis factor Homo sapiens