Title : Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion.

Pub. Date : 2015 May 14

PMID : 25971889






3 Functional Relationships(s)
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1 In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases). Quercetin protein tyrosine kinase 2 Homo sapiens
2 In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases). Quercetin protein tyrosine kinase 2 Homo sapiens
3 More importantly, overexpression of FAK or PAK significantly reduced the inhibitory effect of quercetin on the migration of the melanoma cells. Quercetin protein tyrosine kinase 2 Homo sapiens