Title : Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies.

Pub. Date : 2015 Apr 16

PMID : 25880481






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Solanezumab accommodates a large Abeta epitope (960 A(2) buried interface over residues 16 to 26) that forms extensive contacts and hydrogen bonds to the antibody, largely via main-chain Abeta atoms and a deeply buried Phe19-Phe20 dipeptide core. Dipeptides amyloid beta precursor protein Homo sapiens