Title : Endothelial-derived oxidative stress drives myofibroblastic activation and calcification of the aortic valve.

Pub. Date : 2015

PMID : 25874717






1 Functional Relationships(s)
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1 Treatment with inflammatory cytokine TNFalpha increased superoxide and oxidative stress and decreased eNOS and VE-cadherin acutely over 48 hours in aortic valve endothelial cells (VEC) and chronically over 21 days in ex vivo AV leaflets. Superoxides tumor necrosis factor Homo sapiens