Title : Protein kinase A defects and cortisol-producing adrenal tumors.

Pub. Date : 2015 Jun

PMID : 25871963






1 Functional Relationships(s)
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1 RECENT FINDINGS: The cyclic AMP-dependent PKA catalytic subunit alpha (PRKACA) hotspot point mutation (c.617A > C [p.Leu206Arg]), leading to an increase of basal PKA activity, and formation of cortisol-producing adenoma has been frequently shown to cause the most common form of adrenocorticotropic hormone-independent Cushing syndrome. Cyclic AMP proopiomelanocortin Homo sapiens