Title : Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: effect of N-acetyl transferase polymorphisms.

Pub. Date : 2015 Mar 28

PMID : 25834322






1 Functional Relationships(s)
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1 NAT1 genotypes corresponding to fast enzymatic activity were associated with reduced TGN concentration (P value linear mixed effects model 0.033), putatively because of increased 5-ASA inactivation and consequent reduced inhibition of thiopurine metabolism. 2-mercaptopyrazine N-acetyltransferase 1 Homo sapiens