Title : Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons.

Pub. Date : 2015 Mar 26

PMID : 25808323






5 Functional Relationships(s)
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1 Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons. Glucose proopiomelanocortin Homo sapiens
2 Here we show that leptin"s action on GABA release to POMC neurons is influenced by glucose levels. Glucose proopiomelanocortin Homo sapiens
3 However, postsynaptic TRPC channel opening by the PI3K-PLC signalling pathway in POMC neurons enhances spontaneous GABA release via activation of presynaptic MC3/4 and mGlu receptors at 2.5 mM glucose. Glucose proopiomelanocortin Homo sapiens
4 Our data indicate that the interplay between glucose and leptin signalling in glutamatergic POMC neurons is critical for determining the strength of inhibitory tone towards POMC neurons. Glucose proopiomelanocortin Homo sapiens
5 Our data indicate that the interplay between glucose and leptin signalling in glutamatergic POMC neurons is critical for determining the strength of inhibitory tone towards POMC neurons. Glucose proopiomelanocortin Homo sapiens