Title : Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways.

Pub. Date : 2015 Mar 4

PMID : 25736434






3 Functional Relationships(s)
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1 Here we show that MSC administration alleviated airway inflammation and emphysema through the down-regulation of cyclooxygenase-2 (COX-2) and COX-2-mediated prostaglandin E2 (PGE2) production, possibly through the effect on alveolar macrophages. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 Here we show that MSC administration alleviated airway inflammation and emphysema through the down-regulation of cyclooxygenase-2 (COX-2) and COX-2-mediated prostaglandin E2 (PGE2) production, possibly through the effect on alveolar macrophages. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
3 In vitro co-culture experiments provided evidence that MSCs down-regulated COX-2/PGE2 in macrophages through inhibition of the activation-associated phosphorylation of p38 MAPK and ERK. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus