Title : Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells.

Pub. Date : 2015 Jun

PMID : 25725292






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TNF-alpha/CHX time-dependently increased intracellular total ROS and mitochondrial superoxide anion production in MODE-K cells, starting from 2h. Superoxides tumor necrosis factor Mus musculus
2 The mitochondrial electron transport chain inhibitors, amytal (IQ site of complex I) and TTFA (Qp site of complex II) showed a pronounced decrease in TNF-alpha/CHX-induced total ROS, mitochondrial superoxide anion and cell death levels. Superoxides tumor necrosis factor Mus musculus
3 The results suggest that mitochondria and NOX are the two major sources of ROS overproduction during TNF-alpha/CHX-induced cell death in MODE-K cells, with superoxide anions being the major ROS species. Superoxides tumor necrosis factor Mus musculus