Title : The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.

Pub. Date : 2015 Feb 17

PMID : 25683716






4 Functional Relationships(s)
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1 The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. Copper synthesis of cytochrome C oxidase 1 Homo sapiens
2 Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Copper synthesis of cytochrome C oxidase 1 Homo sapiens
3 We further demonstrate that the Cu deficiency is explained by a functional connection between SCO1 and CTR1, the high-affinity transporter that imports Cu into the cell. Copper synthesis of cytochrome C oxidase 1 Homo sapiens
4 We further demonstrate that the Cu deficiency is explained by a functional connection between SCO1 and CTR1, the high-affinity transporter that imports Cu into the cell. Copper synthesis of cytochrome C oxidase 1 Homo sapiens