Pub. Date : 2015 Mar
PMID : 25681707
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | CASPASE3 activity and BAX expression were significantly raised in all MEHP-treated groups; BCL2 expression was elevated in 25 mumol/l group, while inhibited in 50 and 100 mumol/l groups; BAX/BCL2 ratio was increased in a typical dose-effect relationship. | mono-(2-ethylhexyl)phthalate | caspase 3 | Rattus norvegicus | ||
| 2 | In conclusion, this study showed that MEHP exposure induced cell viability decrease and apoptosis, associated with increase of CASPASE3 activity and BAX/BCL2 ratio. | mono-(2-ethylhexyl)phthalate | caspase 3 | Rattus norvegicus | ||
| 3 | Moreover, CASPASE3 activity showed a reversed dose-dependent effect in MEHP-treated groups, indicating there might exist other CASPASE-independent pathway involved in MEHP-induced apoptosis. | mono-(2-ethylhexyl)phthalate | caspase 3 | Rattus norvegicus | ||
| 4 | Moreover, CASPASE3 activity showed a reversed dose-dependent effect in MEHP-treated groups, indicating there might exist other CASPASE-independent pathway involved in MEHP-induced apoptosis. | mono-(2-ethylhexyl)phthalate | caspase 3 | Rattus norvegicus | ||