Title : Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.

Pub. Date : 2015 Feb

PMID : 25664730






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes the interconversion of pyruvate and lactate using NADH/NAD(+) as a co-substrate. NAD lactate dehydrogenase A Homo sapiens
2 Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes the interconversion of pyruvate and lactate using NADH/NAD(+) as a co-substrate. NAD lactate dehydrogenase A Homo sapiens
3 The X-ray crystal structures of LDHA in complex with each inhibitor were determined; both inhibitors bind to a site overlapping with the NADH-binding site. NAD lactate dehydrogenase A Homo sapiens
4 Further, an apo LDHA crystal structure solved in a new space group is reported, as well as a complex with both NADH and the substrate analogue oxalate bound in seven of the eight molecules and an oxalate only bound in the eighth molecule in the asymmetric unit. NAD lactate dehydrogenase A Homo sapiens