Pub. Date : 2015 Apr 7
PMID : 25663381
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our data suggest that the activation of the hexosamine biosynthetic pathway directly increased OGT levels and activity, triggering changes in glycosylation and PASMC proliferation. | pasmc | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 2 | Partial knockdown of OGT in IPAH PASMCs resulted in reduced global O-linked beta-N-acetylglucosamine modification levels and abrogated PASMC proliferation. | pasmc | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 3 | CONCLUSIONS: Our data demonstrate that hexosamine biosynthetic pathway flux is increased in IPAH and drives OGT-facilitated PASMC proliferation through specific proteolysis and direct activation of host cell factor-1. | pasmc | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |