Pub. Date : 2015 Apr 16
PMID : 25661252
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, in response to 50muM NMDA conditions that induced neuronal cell apoptosis, nuclear-distributed HDAC5 was rapidly phosphorylated and translocated into cytoplasm of the cultured cortical neurons. | N-Methylaspartate | histone deacetylase 5 | Homo sapiens |
| 2 | Treatment with a CaMKII inhibitor KN93 suppressed HDAC5 phosphorylation and nuclear translocation induced by NMDA, whereas constitutively active CaMKIIalpha (T286D) stimulated HDAC5 nuclear export. | N-Methylaspartate | histone deacetylase 5 | Homo sapiens |
| 3 | Importantly, we showed that ectopic expression of nuclear-localized HDAC5 in cortical neurons suppressed NMDA-induced apoptosis. | N-Methylaspartate | histone deacetylase 5 | Homo sapiens |
| 4 | Finally, inactivation of HDAC5 by treatment with the class II-specific HDAC inhibitor trichostatin A (TSA) promoted NMDA-induced neuronal cell apoptosis. | N-Methylaspartate | histone deacetylase 5 | Homo sapiens |