Title : Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways.

Pub. Date : 2015 Feb 15

PMID : 25592323






1 Functional Relationships(s)
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1 7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels. 25-hydroxycholesterol Wistar clone pR53P1 p53 pseudogene Rattus norvegicus