Title : Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

Pub. Date : 2015 Jan 15

PMID : 25590800






2 Functional Relationships(s)
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1 Here, we describe a series of indole-2-carboxylic acids, exemplified by the compound A-1210477, that bind to MCL-1 selectively and with sufficient affinity to disrupt MCL-1-BIM complexes in living cells. indole-2-carboxylic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Here, we describe a series of indole-2-carboxylic acids, exemplified by the compound A-1210477, that bind to MCL-1 selectively and with sufficient affinity to disrupt MCL-1-BIM complexes in living cells. indole-2-carboxylic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens