Title : Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.

Pub. Date : 2015 Mar

PMID : 25584415






1 Functional Relationships(s)
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1 Thus, EGF-promoted Ser-727 phosphorylation by ERK-1/2 is not only sufficient to fully activate hypothalamic STAT-3, but, in terms of targeted genes and required cofactors, entails distinct modes of STAT-3 actions compared with IFN-gamma-induced Tyr-705 phosphorylation. Tyrosine epidermal growth factor Homo sapiens