Title : Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549.

Pub. Date : 2015 Apr

PMID : 25539072






12 Functional Relationships(s)
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Protein Name
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1 Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. fangchinoline protein tyrosine kinase 2 Homo sapiens
2 Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. fangchinoline protein tyrosine kinase 2 Homo sapiens
3 RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines. fangchinoline protein tyrosine kinase 2 Homo sapiens
4 RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines. fangchinoline protein tyrosine kinase 2 Homo sapiens
5 And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline. fangchinoline protein tyrosine kinase 2 Homo sapiens
6 And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline. fangchinoline protein tyrosine kinase 2 Homo sapiens
7 And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline. fangchinoline protein tyrosine kinase 2 Homo sapiens
8 DISCUSSION: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways. fangchinoline protein tyrosine kinase 2 Homo sapiens
9 CONCLUSION: Fangchinoline could inhibit the phosphorylation of FAK(p-Tyr397), at least partially. fangchinoline protein tyrosine kinase 2 Homo sapiens
10 Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line. fangchinoline protein tyrosine kinase 2 Homo sapiens
11 Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line. fangchinoline protein tyrosine kinase 2 Homo sapiens
12 Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line. fangchinoline protein tyrosine kinase 2 Homo sapiens