Pub. Date : 2015 Apr
PMID : 25539072
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 2 | Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 3 | RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 4 | RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 5 | And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 6 | And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 7 | And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 8 | DISCUSSION: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 9 | CONCLUSION: Fangchinoline could inhibit the phosphorylation of FAK(p-Tyr397), at least partially. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 10 | Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 11 | Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |
| 12 | Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line. | fangchinoline | protein tyrosine kinase 2 | Homo sapiens |