Title : In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome.

Pub. Date : 1989 Aug

PMID : 2549753






3 Functional Relationships(s)
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1 The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson"s syndrome were studied in vitro. Ketoconazole proopiomelanocortin Homo sapiens
2 The hormone released in the culture medium decreased depending on the doses of ketoconazole used; 10 mumol/l decreased ACTH levels by 31%. Ketoconazole proopiomelanocortin Homo sapiens
3 These data show that ketoconazole induce marked changes on corticotrope morphology and ACTH secretion in pituitary cells obtained from patients with Nelson"s syndrome. Ketoconazole proopiomelanocortin Homo sapiens