Title : Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.

Pub. Date : 2015 Feb 15

PMID : 25477469






2 Functional Relationships(s)
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1 Melphalan had no significant inhibitory effect on any OAT, whereas chlorambucil reduced OAT1-, OAT3-, and OAT4-mediated uptake of PAH or ES down to 14.6%, 16.3%, and 66.0% of control, respectively. Einsteinium solute carrier family 22 member 8 Homo sapiens
2 Bendamustine inhibited only OAT3-mediated ES uptake, which was reduced down to 14.3% of control cells, suggesting that it interacts exclusively with OAT3. Einsteinium solute carrier family 22 member 8 Homo sapiens