Title : Glial cell line-derived neurotrophic factor promotes β-catenin phosphorylation and nuclear translocation in glioma cells.

Pub. Date : 2015 Dec

PMID : 25423132






4 Functional Relationships(s)
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1 To determine if Src induced phosphorylation of beta-catenin Tyr-654, Western blot analysis was also performed on nuclear proteins from C6 cells treated with tyrosine kinase inhibitor PP2 using then p- beta-catenin antibody. Tyrosine catenin beta 1 Homo sapiens
2 RESULTS: After induced by GDNF, C6 cell membrane beta-catenin was phosphorylated at Tyr-654 and subsequently separated from the N-cadherin/beta-catenin complex. Tyrosine catenin beta 1 Homo sapiens
3 Further study confirmed that the induction by GDNF significantly increased cytoplasmic and nuclear expression of phospho-beta-catenin (Tyr-654) in C6 glioma cells. Tyrosine catenin beta 1 Homo sapiens
4 Src induced phosphorylation of beta-catenin Tyr-654 induced by GDNF decreased significantly. Tyrosine catenin beta 1 Homo sapiens