Title : Prostaglandin E2 EP1 receptor enhances TGF-β1-induced mesangial cell injury.

Pub. Date : 2015 Jan

PMID : 25352206






2 Functional Relationships(s)
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1 Studies have found that the expression level of prostaglandin E2 (PGE2) in MCs increases under high glucose conditions, that PGE2 affects the proliferation and hypertrophy of MCs mainly through the EP1 pathway, and that the proliferation of MCs and the accumulation of extracellular matrix are the main events leading to glomerular fibrosis. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 Studies have found that the expression level of prostaglandin E2 (PGE2) in MCs increases under high glucose conditions, that PGE2 affects the proliferation and hypertrophy of MCs mainly through the EP1 pathway, and that the proliferation of MCs and the accumulation of extracellular matrix are the main events leading to glomerular fibrosis. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus