Title : Structural insight into the MC4R conformational changes via different agonist-mediated receptor signaling.

Pub. Date : 2014 Nov 18

PMID : 25347793






3 Functional Relationships(s)
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1 Previous studies indicate that alpha-melanocyte stimulating hormone (alpha-MSH) binds to MC4R and activates three signal pathways (cAMP, calcium, and mitogen-activated protein kinase pathways), whereas MC4R synthetic agonist THIQ can activate only the cAMP pathway. Cyclic AMP proopiomelanocortin Homo sapiens
2 Previous studies indicate that alpha-melanocyte stimulating hormone (alpha-MSH) binds to MC4R and activates three signal pathways (cAMP, calcium, and mitogen-activated protein kinase pathways), whereas MC4R synthetic agonist THIQ can activate only the cAMP pathway. Cyclic AMP proopiomelanocortin Homo sapiens
3 Previous studies indicate that alpha-melanocyte stimulating hormone (alpha-MSH) binds to MC4R and activates three signal pathways (cAMP, calcium, and mitogen-activated protein kinase pathways), whereas MC4R synthetic agonist THIQ can activate only the cAMP pathway. Cyclic AMP proopiomelanocortin Homo sapiens