Pub. Date : 2014
PMID : 25330300
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 2 | Therefore, we analyzed here whether a genetic imbalance of the manganese-dependent superoxide dismutase (SOD2) gene could have some impact on the MTX cytotoxic response. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 3 | AA-PBMCs that present higher SOD2 efficiencies were more resistance to high MTX doses (10 and 100 microM) than were the VV and AV genotypes. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 4 | The AA-PBMCs exposed to MTX showed decreasing SOD2 activity, but a concomitant up regulation of the SOD2 gene was observed. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 5 | The AA-PBMCs exposed to MTX showed decreasing SOD2 activity, but a concomitant up regulation of the SOD2 gene was observed. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 6 | Caspase-8 and -3 levels were increased in cells exposed to MTX, but the modulation of these genes, as well as that of the Bax and Bcl-2 genes involved in the apoptosis pathway, presented a modulation that was dependent on the SOD2 genotype. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 7 | MTX at a concentration of 10 microM also increased inflammatory cytokines (IL-1beta, IL-6, TNFalpha and Iggamma) and decreased the level of IL-10 anti-inflammatory cytokine, independent of SOD2 genetic background. | Methotrexate | superoxide dismutase 2 | Homo sapiens |
| 8 | The results suggest that potential pharmacogenetic effect on the cytotoxic response to MTX due differential redox status of cells carriers different SOD2 genotypes. | Methotrexate | superoxide dismutase 2 | Homo sapiens |