Title : Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications.

Pub. Date : 2014 Nov 15

PMID : 25318062






2 Functional Relationships(s)
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1 Interestingly, phospho-MARCKS acted in parallel with increased phosphatidylinositol (3,4,5)-triphosphate pools and AKT activation in cells. phosphatidylinositol 3,4,5-triphosphate myristoylated alanine rich protein kinase C substrate Homo sapiens
2 Through treatment with a 25-mer peptide targeting the MARCKS PSD motif (MPS peptide), we were able to suppress tumor growth and metastasis in vivo, and reduced levels of phospho-MARCKS, phosphatidylinositol (3,4,5)-triphosphate, and AKT activity. phosphatidylinositol 3,4,5-triphosphate myristoylated alanine rich protein kinase C substrate Homo sapiens