Title : A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.

Pub. Date : 2014

PMID : 25259522






2 Functional Relationships(s)
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1 Moreover, down-regulation of this expression by small interfering RNAs specific to the IRAK-M gene significantly reverses the anti-inflammatory effect of nicotine on LPS-induced TNF-alpha production. Nicotine tumor necrosis factor Homo sapiens
2 Interestingly, macrophages pre-exposed to nicotine exhibit higher IRAK-M levels and reduced TNF-alpha response to an additional LPS challenge, a behavior reminiscent of the "endotoxin tolerant" phenotype identified in monocytes either pre-exposed to LPS or from immunocompromised septic patients. Nicotine tumor necrosis factor Homo sapiens