Title : A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.

Pub. Date : 2014

PMID : 25259522






2 Functional Relationships(s)
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1 A signaling pathway downstream from the alpha7 nAChRs, which involves the collaboration of JAK2/STAT3 and NF-kappaB to interfere with signaling by Toll-like receptors (TLRs), has been implicated in this anti-inflammatory effect of nicotine. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 By using selective inhibitors of different signaling molecules downstream from the receptor, we provide evidence that activation of STAT3, via either JAK2 and/or PI3K, through a single (JAK2/PI3K/STAT3) or two convergent cascades (JAK2/STAT3 and PI3K/STAT3), is necessary for nicotine-induced IRAK-M expression. Nicotine signal transducer and activator of transcription 3 Homo sapiens