Title : Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5).

Pub. Date : 2015 Mar 26

PMID : 25234355






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1 Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-beta type-I receptor kinase (ALK5). imidazo(2,1-b)(1,3,4)thiadiazole transforming growth factor beta 1 Homo sapiens
2 A new series of imidazo[2,1-b][1,3,4]thiadiazoles 5(a-g), 6(a-g), 9(a-i) and 12(a-h) were synthesized as transforming growth factor-beta (TGF-beta) type I receptor (also known as activin receptor-like kinase 5 or ALK5) inhibitors. imidazo(2,1-b)(1,3,4)thiadiazole transforming growth factor beta 1 Homo sapiens