Title : Enhanced breast cancer cell adherence to the lung endothelium via PAF acetylhydrolase inhibition: a potential mechanism for enhanced metastasis in smokers.

Pub. Date : 2014 Nov 15

PMID : 25186013






1 Functional Relationships(s)
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1 Pretreatment of HMVEC-L with (S)-bromoenol lactone to inhibit calcium-independent phospholipase A2beta (iPLA2beta, which initiates endothelial cell PAF production) prior to CSE exposure resulted in complete inhibition of MDA-MB-231 cell adherence. Calcium phospholipase A2 group VI Homo sapiens