Title : β-catenin contributes to lung tumor development induced by EGFR mutations.

Pub. Date : 2014 Oct 15

PMID : 25164010






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Mutant EGFR preferentially bound to and tyrosine phosphorylated beta-catenin, leading to an increase in beta-catenin-mediated transactivation, particularly in cells harboring the gefitinib/erlotinib-resistant gatekeeper EGFR-T790M mutation. Tyrosine catenin beta 1 Homo sapiens
2 Mutant EGFR preferentially bound to and tyrosine phosphorylated beta-catenin, leading to an increase in beta-catenin-mediated transactivation, particularly in cells harboring the gefitinib/erlotinib-resistant gatekeeper EGFR-T790M mutation. Tyrosine catenin beta 1 Homo sapiens