Pub. Date : 2014 Dec
PMID : 25110320
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A net up-regulation of survival signaling, involving the extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt phosphorylation pathways, was observed in U937 promonocytic cells cultivated over time in the presence of a low micromolar concentration of the oxysterol. | Oxysterols | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | In turn, stimulation of ERK and PI3K/Akt both significantly quenched ROS steady state and markedly phosphorylated Bad, thereby determining a marked delay of the oxysterol s proapoptotic action. | Oxysterols | mitogen-activated protein kinase 1 | Homo sapiens |