Title : Osteocyte-specific deletion of Fgfr1 suppresses FGF23.

Pub. Date : 2014

PMID : 25089825






1 Functional Relationships(s)
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1 Fgfr1Dmp1-cKO-null mice exhibited a 50% reduction in FGF23 expression in bone and 3-fold reduction in serum FGF23 concentrations, as well as reductions in sclerostin (Sost), phosphate regulating endopeptidase on X chromosome (PHEX or Phex), matrix extracellular phosphoglycoprotein (Mepe), and Dmp1 transcripts, but had no demonstrable alterations in phosphate or vitamin D homeostasis or skeletal morphology. Vitamin D dentin matrix protein 1 Mus musculus