Title : Attenuation of IFN-γ-induced B7-H1 expression by 15-deoxy-delta(12,14)-prostaglandin J2 via downregulation of the Jak/STAT/IRF-1 signaling pathway.

Pub. Date : 2014 Sep 1

PMID : 25072357






2 Functional Relationships(s)
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1 These effects of 15d-PGJ2 were not abrogated by the PPARgamma antagonist GW9662, indicating that they occur through a PPARgamma-independent mechanism. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
2 SIGNIFICANCE: In this study, we demonstrate that 15d-PGJ2 suppresses the IFN-gamma-elicited expression of B7-H1 by the inhibition of IRF-1 transcription via the Jak/STAT signaling pathway through a PPARgamma-independent mechanism in mouse melanoma cells. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus