Title : Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

Pub. Date : 2014 Aug 15

PMID : 25037916






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Biochemical and surface plasmon resonance experiments performed with a screening hit (LDHA IC50=1.7 muM) indicated that the compound specifically associated with human LDHA in a manner that required simultaneous binding of the NADH co-factor. NAD lactate dehydrogenase A Homo sapiens
2 Biochemical and surface plasmon resonance experiments performed with a screening hit (LDHA IC50=1.7 muM) indicated that the compound specifically associated with human LDHA in a manner that required simultaneous binding of the NADH co-factor. NAD lactate dehydrogenase A Homo sapiens