Title : Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder.

Pub. Date : 2014 Sep

PMID : 24952092






3 Functional Relationships(s)
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1 OBJECTIVE: The present study examined the effects of sex and PTSD on adrenocorticotropic hormone (ACTH), progesterone, and allopregnanolone responses to metyrapone and whether progesterone and allopregnanolone reactivity could affect the ACTH response in PTSD. Metyrapone proopiomelanocortin Homo sapiens
2 RESULTS: The increase in ACTH response to metyrapone was higher in PTSD subjects compared to controls and in women compared to men. Metyrapone proopiomelanocortin Homo sapiens
3 CONCLUSIONS: Our findings of increased ACTH to metyrapone in PTSD and in women may reflect heightened hypothalamic CRF hypersecretion. Metyrapone proopiomelanocortin Homo sapiens